In MYCamp-G3-MB, SPT16 does not fulfill the first two criteria despite exhibiting crucial cancer-dependency, whereas in another MYC family member driven malignant pediatric solid tumor, MYCN-amplified neuroblastoma (MYCNamp-NB), SPT16 is the major oncogenic player instead of SSRP142. The gene discussed is SUPT16H; the disease is neuroblastoma.