VRK1 and cancer: Eight epigenetic genes (CBX1, HMGA1, PRC1, RCOR1, RUVBL2, SRSF3, SSRP1, and VRK1) were found to meet all above-mentioned criteria, whereas only SSRP1 has targeted drug tested in human clinical trial and its role in tumorigenesis or cancer therapy has not been reported in MYCamp-G3-MB before (Fig. 1B).