On the other hand, some studies suggested suppressive roles of SKIL on the proliferation and survival in some specific pathological subtypes of cancer (e.g. lower grade esophageal adenocarcinoma, lower grade ovarian adenocarcinoma, pancreatic adenocarcinoma, and breast ductal adenocarcinoma22), and silencing of SKIL (or SnoN) upregulated proliferation of ESCC cell line23, indicating a complex of SKIL in tumorigenesis. Here, SKIL is linked to esophageal squamous cell carcinoma.