Therefore, we also measured levels of TAZ and its downstream pro-tumorigenesis factors, and results showed decreased levels of TAZ and its downstream factors (CTGF, CYR61) in SKIL-silenced cell lines (Fig. 4d), suggesting that SKIL might regulate autophagy via regulation on the TAZ pathway in NSCLC. The gene discussed is CCN2; the disease is non-small cell lung carcinoma.