BRPF1 and Neurodevelopmental delay: A previous study revealed that butyrate alleviated the acylation deficiency (caused by the mutations of in the bromodomain- and PHD finger-containing protein 1 Brpf1 gene) of histone H3 at lysine 23 in mouse embryos and fibroblasts and human embryonic kidney 293 cells, and this deficiency was also found in children with neurodevelopmental delay (32).