Previous immunohistochemical study found that JAG1 expression was significantly higher in intraductal papillary mucinous carcinoma than in intraductal papillary mucinous adenoma and was significantly related to recurrence, suggesting that JAG1 levels also reflect IPMN aggressiveness (25). The gene discussed is JAG1; the disease is pancreatic intraductal papillary-mucinous neoplasm.