Indeed, immunostaining in KJC mice found that ductal cells lining SCN-like lesions were completely negative for Sox9, and IPMN-like lesions showed no or very weak Sox9 staining, whereas a rarely formed PDAC showed clear nuclear staining of Sox9 in ductal tumor cells (Fig 5A–C). This evidence concerns the gene SOX9 and pancreatic intraductal papillary-mucinous neoplasm.