With the same Sox9-CreER, concurrent Lkb1 deletion and Kras activation in the ductal epithelium resulted in IPMN in adult mice (36), whereas deletion of Jag1 combined with KrasG12D expression in the ductal epithelium failed to induce cystic neoplasm. The gene discussed is STK11; the disease is pancreatic intraductal papillary-mucinous neoplasm.