With the same Sox9-CreER, concurrent Lkb1 deletion and Kras activation in the ductal epithelium resulted in IPMN in adult mice (36), whereas deletion of Jag1 combined with KrasG12D expression in the ductal epithelium failed to induce cystic neoplasm. This evidence concerns the gene SOX9 and pancreatic intraductal papillary-mucinous neoplasm.