PDX1 and Pancreatic cysts: At 3 mo and older, 34.5% KJC mice (n = 29) and 10.5% KrasLSL-G12D/+;Jag1flox/+;Pdx1-Cre mice (n = 19) showed distended abdomen because of large-size pancreatic cysts containing clear to straw-colored fluid (Fig 2N), highlighting the importance of the gene dosage in this SCN/IPMN phenotype.