In certain tumor types (eg, squamous cell carcinoma of the head and neck (SCCHN), melanoma, breast cancer and renal cell carcinoma (RCC)), PD-L1 is expressed on the surface of both tumor and immune cells (macrophages, dendritic cells, and activated T cells), whereas in others such as colorectal cancer (CRC) and gastric carcinoma, PD-L1 expression is predominantly seen on tumor-infiltrating immune cells. The gene discussed is CD274; the disease is breast cancer.