CD274 and neoplasm: While PD-L1 IHC tests allow for enrichment of patients who are likely to derive clinical benefit from anti-PD-(L)1 agents, their clinical utility is less clear in the context of combination immunotherapies (eg, nivolumab/ipilimumab, angio-immunotherapy, and chemoimmunotherapy) which, based on currently available data, appear to be efficacious irrespective of tumor PD-L1 status.