Furthermore, tumor-infiltrating CD103+ CD39+ CD8+ T cells that display an exhausted Trm phenotype showed an enrichment for tumor-specific cells with a distinct tumor-specific TCR repertoire; contrary to what their exhausted phenotype might suggest, they efficiently kill autologous tumor cells in a major histocompatibility complex (MHC) class I-dependent manner, and their frequencies positively correlate with OS in patients with SCCHN. This evidence concerns the gene ITGAE and neoplasm.