NOS2 and Reye syndrome: On the other hand, significant reduction of the expression of pro-inflammatory cytokines is seen in CSKO knockout parasites IL1β (*P<0.05), TNFα (***P<0.001) and IFNγ (*P<0.05) (Fig. 4B–D) was observed as compared to the mice infected with the wild-type parasite showing decreased activation of immune system and oxidative damage mediated by iNOS, which is responsible for Reye's syndrome.