IMG7289 (bomedemstat), an LSD1 inhibitor, reduced splenomegaly, normalized blood counts, and prolonged survival in the Jak2 V617F murine model [39], which has led to the clinical evaluation of bomedemstat as a second-line agent in PV and ET (NCT04254978) (NCT04262141). This evidence concerns the gene JAK2 and acquired polycythemia vera.