Moreover, the overexpression of miR-34c, a tumor suppressor, significantly increased the levels of eIF2α and IRE1α by directly targeting the 3ʹUTR of HMGB1 and inhibits HMGB1 translation, promoting non-small cell lung cancer (NSCLC) apoptosis [93]. This evidence concerns the gene ERN1 and non-small cell lung carcinoma.