EIF2AK3 and cancer: However, sinoporphyrin sodium-induced photodynamic therapy (DVDMS-PDT) can downregulate miR-7112-3p in CX-1 cells, which directly acts on PERK and further regulates the PERK-ATF4-CHOP-Caspase3/8 signaling pathway, increasing DVDMS-PDT-induced cancer cell apoptosis [174].