Previous studies have observed changes in chronic pain through the inhibition of mTOR signaling in the spinal cord [38–41], and recent studies have demonstrated effective modulation of chronic pain by direct mTOR signaling control in the brain [16, 32, 42], The activation of mTOR regulates protein synthesis by phosphorylating downstream effectors, which influence a wide range of physiological and pathological states, including neuropathic, inflammatory, and cancer-related pain [16–18]. This evidence concerns the gene MTOR and cancer.