SLC8A1 and Hypertension: Li et al. found that compared with those in the WKY rats group with normal blood pressure, the Na + −Ca2+ exchanger and phospholamban proteins in SHRs myocardial cells increased significantly, while SERCA2a decreased significantly, which confirmed that due to abnormal SR and cell membrane processing of Ca2+ in hypertension, the systolic function was changed [24].