According to in vitro and in vivo studies, metformin, thiazolidinedione (TZD), and dipeptidyl peptidase-4 (DPP-4) inhibitors produce anti-inflammatory effects by decreasing inflammatory biomarker levels [11, 12], activating peroxisome proliferator-activated receptor-γ [13], or improving insulin resistance [14, 15], but several OHAs, such as sulfonylureas, meglitinides, and α-glucosidase inhibitors, have not been fully assessed regarding their effects in inflammation and COPD. This evidence concerns the gene DPP4 and Insulin resistance.