This lncRNA-protein interaction increases MIR22HG stability and regulates the subcellular localization of HuR, resulting in the decreased expression of HuR-stabilized oncogenes such as β-catenin, CCNB1 (encoding cyclin B1), HIF1A (encoding hypoxia-inducible factor-1α), BCL2 (encoding apoptosis regulator Bcl2), COX2 (encoding cyclooxygenase COX2), and C-FOS (encoding the nuclear phospho-protein c-Fos) and thereby inhibiting the proliferation, invasion and migration of HCC (Fig. 4b). The gene discussed is CCNB1; the disease is hepatocellular carcinoma.