In further support of the mutp53-Nek2 association in human cancer, a retrospective analysis of the Metabric cohort of breast cancer patients (www.cbioportal.org) demonstrated a significantly higher median of Nek2 mRNA expression in mutp53 patients, regardless of the mutation type, as compared to patients with wtp53 (Fig. 4h). This evidence concerns the gene NEK2 and breast carcinoma.