In addition to the loss of wtp53 function, mutp53 in H/−;ErbB2 cells upregulates Nek2 expression in apparent GOF manner as stabilized mutp53 protein in H/−;ErbB2 cancer cells was associated with a higher level of Nek2 mRNA and protein levels compared to −/−;ErbB2 cancer cells (Fig. 4d) or following mutp53 ablation by CRISPR/Cas9 (Fig. 4e). Here, ERBB2 is linked to cancer.