CD8A and neoplasm: Therefore, our data demonstrate that higher expression of PD-L1 in the stage IV IBC tumor microenvironment (TME) increases cytolytic granule components in blood NK and CD4+ T cells and appears to shift the CD8+ T cell pool from naïve toward an effector memory phenotype in peripheral blood, suggesting that an immune response had occurred in many of these patients, presumably toward the IBC tumor.