Therefore, our data demonstrate that higher expression of PD-L1 in the stage IV IBC tumor microenvironment (TME) increases cytolytic granule components in blood NK and CD4+ T cells and appears to shift the CD8+ T cell pool from naïve toward an effector memory phenotype in peripheral blood, suggesting that an immune response had occurred in many of these patients, presumably toward the IBC tumor. The gene discussed is CD274; the disease is neoplasm.