CD4 and asthma: However, some clinical studies also validated these roles when treatment with glucocorticosteroids in asthmatics might increase this FOXP3 protein expression within Tregs in humans, and revealed the suppression of Tregs number as reported from lung tissue in a model of asthma [63] while asthmatic patients have been reported to show decreased FOXP3 protein expression within their CD4+ CD25high T regulatory cells repertoire [116].