RCAN1 reduction is beneficial to atherosclerosis (Mendez-Barbero et al. 2013) whereas RCAN1 protects against myocardial ischemia/reperfusion injury (Rotter et al. 2014), myocardial hypertrophy (Sussman et al. 1998) and intramural hematoma /aortic rupture (Villahoz et al. 2018). The gene discussed is RCAN1; the disease is myocardial ischemia.