LAD1 and colorectal cancer: Our findings show that (i) the expression of LAD1 transcript correlates with poor prognosis of colorectal cancer patients, (ii) depletion of LAD1 impairs the metastatic potential of colorectal cancer cells in vitro and in vivo, and (iii) elevated expression of LAD1 protein in tissues is associated with the metastatic stage of colorectal cancer.