TFE3 and hereditary clear cell renal cell carcinoma: Xp11.2 translocation renal cell carcinoma (Xp11.2 translocation RCC) is a rare subtype of renal cell carcinoma (RCC), characterized by several different chromosomal translocations involving Xp11.2 and the formation of TFE3 fusion genes, followed by overexpression of TFE3 protein [6].