Finally, there are two known hereditary conditions predisposing to gastric cancer, mutation of the CDH 1 gene coding for E-cadherin predisposing to diffuse gastric cancer at young age [117] and mutation of the ATP4A gene coding for one of the genes of the proton pump leading to ECL cell derived tumours of variable malignancy [90,91] (Table 2). This evidence concerns the gene ATP4A and neoplasm.