While Aziz et al. (2001) reported the encouraging detection of cathepsin D or p53 expression for IBC and disease progression, in the context of pregnancy/lactation associated breast carcinoma (PAC), no significant differences in survival between controls and p53 or cathepsin D expression were observed in the 379 samples tested using IHC and flow cytometry analysis [142]. Here, CTSD is linked to inflammatory breast carcinoma.