Similarly, to LMS, the PI3K/AKT/mTOR signaling pathway is often aberrantly activated in Ewing’s sarcoma (ES) [14,15], rhabdomyosarcoma, a well-known pediatric sarcoma of soft tissues displaying very similar histology and therapeutic options with ES [16], osteosarcoma (OS) [17,18], thereby illustrating that the PI3K/AKT/mTOR pathway is a suitable therapeutic target for STS as well as for other human cancers. This evidence concerns the gene AKT1 and Ewing sarcoma.