This might be due to enhanced basal level of expression of phosphorylated form of AKT in STS and GIST cells and also in consistency with previous findings, illustrating that Dox treatment enhances AKT phosphorylation in sarcoma cell lines when was used in a high dose (10M), whereas no increase of AKT phosphorylation was observed when the cells were treated with 1M of Dox [38], which was similar to our experimental conditions. This evidence concerns the gene AKT1 and telomere syndrome.