The most sensitive for AKT inhibition were Dox-treated RD rhabdomyosarcoma cells (Figure 2A), U2-OS osteosarcoma (Figure 2B), GIST T-1R (Figure 2D) and 430 (Figure 2E) which was evidenced by a substantial cell death after the treatment with Dox and MK-2206. The gene discussed is AKT1; the disease is rhabdomyosarcoma.