SMAD4 and familial pancreatic carcinoma: Indeed, pancreatic cancer cells are characterized by a hypermutated landscape, with four most commonly mutated genes: the Kirsten rat sarcoma (KRAS) oncogene, the tumor suppressor protein 53 (TP53), the cyclin dependent kinase inhibitor 2A (CDKN2A), and the SMAD family member 4 (SMAD4) tumor suppressor genes [6].