TCF4 and colorectal carcinoma: It is worth noting that while in this study, no direct evidence was presented to denote BCL-2 as a target gene of WNT/β-catenin signaling in CRC cells, previous studies have proven a direct binding of TCF4 to the promoter of the BCL-2 gene in human CRC cell lines HT-29 and SW620 [32,33].