There are a few aaRSs that are downregulated in multiple cancer types, including HARS2 (n = 6), WARS1 (n = 4), CARS2 (n = 4), IARS1 (n = 3), RARS2 (n = 3), VARS2 (n = 3), and AIMP3/EEF1E1 (n = 3), suggesting these aaRSs may possess certain specific cancer-inhibiting roles. This evidence concerns the gene IARS1 and cancer.