Increased ROS production, together with inflammation, is a common feature in obese and diabetic patients; in addition, in NAFLD subjects, the increased flux of FFAs from the adipose tissue to the liver, due to the impaired lipolysis caused by AT-IR, determines a fat overload in the hepatocytes, promoting oxidative stress and enhancing SeP synthesis. Here, SELENOP is linked to metabolic dysfunction-associated steatotic liver disease.