The link between oxidative stress and IR has been described in several studies reporting that an inflamed adipose tissue is able to release several pro-inflammatory factors, such as interleukin-6 (IL-6) and monocyte chemotactic protein-1 (MCP-1), which in turn exacerbate inflammation, IR and oxidative stress, predisposing the development of NASH and diabetes [21]. Here, CCL2 is linked to diabetes mellitus.