These findings cope well with bibliographic evidence that atypical HNSC is not dependent on the RAS pathway for tumorigenesis [41], which, in this tumor subtype could thus be rather involved in other activities, and that Collagen XIX is crucial for basement membranes’ organization [42] and its loss precedes basement membrane’s invasion in ductal breast carcinoma, possibly due to the disappearance of its anti-tumoral non-collagenous domain 1 (NC1) from the TME [43,44]. This evidence concerns the gene COL18A1 and neoplasm.