For example, our approach pinpoints the link between semaphorin 4D (SEMA4D) and both neural signaling and cell-to-cell adhesion gene programs in neurological neoplasms (Glioblastoma Multiforme, GBM, and Brain Lower Grade Glioma, LGG), as expected from current knowledge [31,32], but also evidences a link between SEMA4D, Runt-related transcription factor 3 (RUNX3) and kinase signaling in Head and Neck Squamous Cell Carcinoma (HNSC,Table S1). The gene discussed is SEMA4D; the disease is glioblastoma.