PLAU and brain cancer: Additionally, we identify only 1 marker not being regulated by an intrinsic factor (BMP3 in lung adenocarcinoma, LUAD, subtype LUAD.5, regressing with the stromal/immune fraction) and three being regulated by miRNAs (PLAU in bladder cancer, BLCA, subtype BLCA.3, TGFB2 in brain cancers, subtype GBM_LGG.Mesenchymal-like and MMP24 again in LUAD.5), suggesting that the landmark matrisome genes we identified are of pure tumor origin and, for the very most, under the direct control of genetic programs rather than epigenetic mechanisms.