Since the immune contribution is crucial in the tumor microenvironment to sustain the progression of the disease, and taking into account that the M2 macrophages localize in the hypoxic regions of lung tumors, miR-181a could have a critical role through specific targets, such as SGK1, which is reported to be involved in the regulation of macrophage polarization [130,131] and is also activated by hypoxic stimuli [130,132,133]. Here, SGK1 is linked to neoplasm.