In NSCLC, the chromosomal region including NDRG1 is consistently amplified and the gene over-expressed [210] SGK1 can promote stem-like properties of lung cancer cells by preventing c-Myc degradation through ubiquitination operated by the S-phase kinase-associated protein 2 (Skp2). The gene discussed is SKP2; the disease is non-small cell lung carcinoma.