However, and beyond the RCT, these particles negatively influence other important metabolic pathways involved in heart disease, including a reduced capacity for lecithin; less cholesterol acyltransferase (LCAT) to convert free cholesterol to cholesterol esters; and a diminished capacity to deliver cholesterol esters to hepatic cells via SR-BI receptor for excretion in the bile [28,32]. The gene discussed is LCAT; the disease is heart disorder.