Pathway enrichment analysis revealed that these 404 genes are critically involved in 16 signaling transduction pathways: Alzheimer disease, thermogenesis, choline metabolism in cancer, renin secretion, Parkinson disease, oxidative phosphorylation, gap junction, glutamatergic synapse, cortisol synthesis and secretion, long-term potentiation, degradation of valine, leucine, and isoleucine, endocytosis, complement and coagulation cascades, propanoate metabolism, legionellosis, and the phospholipase D signaling pathway (Figure S3C). This evidence concerns the gene REN and early-onset autosomal dominant Alzheimer disease.