AKT1 and cancer: It plays an oncogenic role in promoting cancer cell proliferation and metastasis through the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin pathways [9,12,13,14,15,16,17].