According to Cho et al., an experimental mice group to which chlorogenic acid (0.2 g/kg diet) was administered for 8 weeks also decreased epididymal fat and perirenal fat weight, while PPAR-α expression increased, as compared to obese mice induced to obesity by an HFD (37 kcal% from fat) [36]. Here, PPARA is linked to obesity due to melanocortin 4 receptor deficiency.