TGFβ1 signaling to PI3Kγ/AKT/RAC1 or through RAC1/ROS mediates cell migration of hepatic stellate cells in liver fibrosis [64] or invasiveness of PDAC cells, respectively [65,66], whereas TGFβ/Smad3 signaling through DOCK4 and RAC1 facilitates lung adenocarcinoma metastasis [67]. This evidence concerns the gene RAC1 and Hepatic fibrosis.