Furthermore, FCM has also made it possible to identify extracellular vesicles (EVs) identified by the molecules CD144+ (VE-cadherin), CD31+ (PECAM-1) and CD62E+ (E-selectin), and collectively, from the pulmonary capillaries of COPD patients; high levels of EVs can occur in plasma, even before clinical symptoms [50]. Here, CDH5 is linked to chronic obstructive pulmonary disease.