In addition, it has been observed that clone-specific Treg cells can potentially contribute to the reduction of CD4+ cells with telomerase reactivity (TERT) and the monitoring in Latency Associated Peptide (LAP)-TGF-β specific Treg cells that participate in the decrease of cellular activity against aberrant cells, which together could complement the analysis strategy and increase the sensitivity to the early diagnosis of lung cancer [83,84]. The gene discussed is TERT; the disease is lung cancer.