Kotsakis et al. [82] have observed differences in the frequencies of naive, effector and terminal subpopulations in cells TregCD4+CD25high circulating in patients with NSCLC, raising the possibility of generating prognostic and predictive value, as well as therapeutic targets by proving the ability to suppress the activation of CD4+ lymphocytes producing IFN-γ. The gene discussed is IFNG; the disease is non-small cell lung carcinoma.