ABCA12 and ichthyosis: Mutations within ABCA12 conserved domains are linked to skin disorders known as ichthyosis, a condition whereby patients are unable to accumulate lipids in the stratum corneum, hence are exposed to life-threatening water loss through the skin [64,65] Functional impact analysis of the amino acid substitution in ABCA12 showed that the change is likely to alter the protein structure and functions.