The two most common ERCC1 single-nucleotide polymorphisms (SNPs) are C118T (rs11615) with a T to C substitution (TT to CT/CC) at Exon 4, C8092A (rs321986) with a C to A substitution (CC to CA/AA) in the 3’-untranslated region and 17677A > C (rs3212961) as they may contribute to cancer susceptibility. Here, ERCC1 is linked to cancer.