AGTR2 and pulmonary arterial hypertension: Interestingly, an increase of angiotensin II receptor AT1 but not AT2 has been described in the pulmonary vasculature of PAH patients [21], which has important implications for potential treatments since the binding of angiotensin II to its AT1 and AT2 receptors has opposite effects, i.e., AT1 signaling is involved in vasoconstriction, oxidative stress, inflammation and proliferation while AT2 signaling results in vasodilation.