Furthermore, among four mRNA clusters of ccRCCs which resulted from unsupervised clustering of global mRNA expression [14], analyses using the recently established GEPIA2 dataset [24] reveal a significant elevation of HERC2P2 in mRNA cluster 2 tumors and significant downregulations of THSD7A expression in all mRNA clusters of ccRCC in comparison to the matched non-tumor controls (Figure 8). This evidence concerns the gene HERC2P2 and nonpapillary renal cell carcinoma.