The HATMSC2-MVs used in this study affect both histologically different cell lines, the ES-2 cells and the OAW-42 cells, by increasing the production of tumor-suppressive cytokines, such as IL-1ra, IL-2, IL-2Ra, IL-12-p40, IL12-p70, IL-15, and IFN-γ. This evidence concerns the gene IL2RA and neoplasm.