The presence of cancer-promoting cytokines and chemokines, such as IL-6, IL-8, GRO-alpha, MIP-1α, MIP-1β, angiopoetin-2, and VEGF, which are associated with tumor growth, metastatic properties, and a poor prognosis, was detected in the supernatants collected from both ES-2 cells and OAW-42 cells. Here, IL6 is linked to neoplasm.