Researchers have made great effects in elaborating inhibitors against WNKs or SPAK/OSR1 to treat hypertension, for example, WNKs kinase inhibitor: WNK463 [146], PP121 [147]; SPAK/OSR1 inhibitors: STOCK1S-14279 and Closantel [148], Rafoxanide [149], Verteporfin [150], STOCK1S-50699, and STOCK2S-26016 [151]. The gene discussed is OSR1; the disease is hypertensive disorder.