This classification distinguishes luminal A (ERα+ and/or PR+, HER2−, low Ki67), luminal B (ERα+ and/or PR+, HER2+/−, high Ki67), HER2 overexpressing cancers (ERα−, PR−, HER2+), and triple negative BC (ERα−, PR−, HER2−) (TNBC) [23]. Here, ESR1 is linked to cancer.