The primary epigenetics compound screen was performed as described in Figure 2A. The results show that several compound classes reduced the growth of all chondrosarcoma cell lines, including Aurora kinase inhibitors, BET protein inhibitors, Fms Related Receptor Tyrosine Kinase 3 (FLT3) inhibitors, HDAC inhibitors, and Janus kinase (JAK) inhibitors (Figure 2B). The gene discussed is HDAC9; the disease is chondrosarcoma.