Furthermore, epigenetic-targeting compound, JQ1, which is an inhibiter of bromo and extra-terminal domain (BET), and targets bromodomain of the protein family members BRD2, BRD3, BRD4, and BRDT, has been identified to suppress POMC expression, supporting the important role of epigenetic control in ACTH synthesis in ACTHomas [108]. The gene discussed is BRD3; the disease is ACTH-producing pituitary gland adenoma.