Moreover, the cut-off is variable between those different diseases: CRP > 12 mg/L have a sensitivity of 98% to diagnose appendicitis, CRP > 30 mg/L have a sensitivity of 78% to diagnose cholecystitis, CRP levels > 210 mg/L discriminated between patients with clinically mild and severe pancreatitis with a sensitivity of 83% and a specificity of 85% [20]. The gene discussed is CRP; the disease is Cholecystitis.