It is important to indicate that IL-8 and MCP-1 are two very potent chemokines, and particularly MCP-1 is the most important chemokine that regulates migration and infiltration of monocytes/macrophages [39], with a relevant pathophysiological role in the development of obesity and its complications [40]. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.