Obesity is considered a low-grade inflammatory condition, that is, a chronic systemic condition involving elevated systemic concentrations of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-1RA, and other inflammatory mediators such as C-reactive protein (CRP) [1,2,3,4,5,6]. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.