In addition, only in obese animals, β2-adrenergic activation increased intracellular expression of anti-inflammatory cytokines IL-10 (Figure 2a) and TGF-β (Figure 2b) and decreased pro-inflammatory cytokines IL-8 (Figure 3a) and MCP-1 (Figure 3b) expression in peritoneal macrophages, reinforcing the anti-inflammatory effect of terbutaline in these cells in obesity. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.