Detection of LRRK2 and distorted membranous organelles in α-synuclein-positive Lewy pathology not only suggests a molecular and functional interaction between LRRK2 and α-synuclein but also provides support for the hypothesis that LRRK2 dysfunction may disrupt organelle trafficking and contribute to the pathogenesis of PD. Here, LRRK2 is linked to Parkinson disease.