LRRK2 and Parkinson disease: In fact, despite the fact that some models show impaired dopaminergic neurotransmission [55,56] and mild parkinsonian motor features at late stages [57], the majority of LRRK2 KI mice do not exhibit selective loss of DA neurons from the SNpc, the hallmark histopathological feature of PD [50,54,55,56,58,59].