GPBAR-1 KO mice on a high-fat diet exhibited significant fat accumulation with body weight gain compared with that of the wild-type mice [79], while in mice, the activation of GPBAR-1 by INT-777 stimulates the release of the incretin GLP-1, protecting from diabetes and obesity [43]. The gene discussed is GPBAR1; the disease is obesity due to melanocortin 4 receptor deficiency.