In particular, the overexpression in prostatitis of type 2 cystatin proteases with anti-inflammatory action, such as cystatin S, cystatin C, cystatin M, cystatin SA, and other protease inhibitors such as alpha-1 antitrypsin in prostatitis, could be regarded as a mechanism to prevent excessive tissue destruction. This evidence concerns the gene SERPINA1 and urogenital neoplasm.