From our previous studies, we observed that our COPD cohort might also show characteristics of systemic inflammation because of increased concentrations of CRP and Fbg [22] that are being common inflammatory parameters as well as extracellular adenosine triphosphate (eATP) [23] and extracellular heat shock protein 70 (eHsp70) [24] which act like damage-associated molecular patterns (DAMPs). The gene discussed is CRP; the disease is chronic obstructive pulmonary disease.