Models that include IL-1β, eATP and eHsp70 might prove to be useful in recognizing COPD patients because of its great predictive value, while combinations of IL-1β, IL-6 and TNFα with CRP, Fbg, eATP and eHsp70 might have a potential in differentiating COPD patients regarding clinical subgroups, with eATP and eHsp70 being particularly useful in identifying patients with severe COPD. Here, CRP is linked to chronic obstructive pulmonary disease.