To assess whether NK cytotoxic function could depend upon MICA/B expression, we checked the expression of MICA/B on primary HCC cell lines, and a relationship was found with target cell killing using PBMC as effectors, but not when using LIL or TIL, suggesting that other factors, such as the inhibitory liver microenvironment, may negatively influence NK cell function in this setting (Figure S6D). Here, MICA is linked to hepatocellular carcinoma.