U87 and U251 GBM cells expressing ERβ1 only triggered a decrease in cell viability through NF-kB downregulation, JAK/STAT and mTOR/S6kinase signaling and a lower migratory and invasive potential, due to a decrease in MMP2 activity [111,112] (Figure 3). The gene discussed is NFKB1; the disease is glioblastoma.