Since high level of aromatase was associated with a poor survival prognosis, treatment of T98G human GBM cells with vitamin D, dexamethasone and mifepristone (progesterone receptor (PR)/glucocorticoid receptor (GR) antagonist), which increased aromatase expression could trigger tumor malignancy [68,69]. The gene discussed is CYP19A1; the disease is glioblastoma.