The mutations in helix H3 of PPARγ LBD included C285Y, Q286P, R288H and S289C identified in patients with colorectal cancer, F287Y, R288C from patients with skin cancer, Q286E from a patient with bladder cancer and R280C from a patient with uterine cancer (Figure 1A and Table S2). The gene discussed is PPARG; the disease is urinary bladder carcinoma.