Interestingly, we found that helix H3 of PPARγ LBD is enriched for mutations that are found in cancers; helix H3 accounts for only 9.4% of the amino acids in the PPARγ LBD but 19.6% of PPARγ LBD mutations found in cancers (19 mutations in helix H3 among 97 mutations distributed in the PPARγ LBD). Here, PPARG is linked to cancer.